Inhibitors of bacterial immune systems: discovery, mechanisms and applications

Research output: Contribution to journal › Review › Research › peer-review

Standard

Inhibitors of bacterial immune systems : discovery, mechanisms and applications. / Mayo-Muñoz, David; Pinilla-Redondo, Rafael; Camara-Wilpert, Sarah; Birkholz, Nils; Fineran, Peter C.

In: Nature Reviews Genetics, Vol. 25, No. 4, 2024, p. 237-254.

Research output: Contribution to journal › Review › Research › peer-review

Harvard

Mayo-Muñoz, D, Pinilla-Redondo, R, Camara-Wilpert, S, Birkholz, N & Fineran, PC 2024, 'Inhibitors of bacterial immune systems: discovery, mechanisms and applications', Nature Reviews Genetics, vol. 25, no. 4, pp. 237-254. https://doi.org/10.1038/s41576-023-00676-9

APA

Mayo-Muñoz, D., Pinilla-Redondo, R., Camara-Wilpert, S., Birkholz, N., & Fineran, P. C. (2024). Inhibitors of bacterial immune systems: discovery, mechanisms and applications. Nature Reviews Genetics, 25(4), 237-254. https://doi.org/10.1038/s41576-023-00676-9

Vancouver

Mayo-Muñoz D, Pinilla-Redondo R, Camara-Wilpert S, Birkholz N, Fineran PC. Inhibitors of bacterial immune systems: discovery, mechanisms and applications. Nature Reviews Genetics. 2024;25(4):237-254. https://doi.org/10.1038/s41576-023-00676-9

Author

Mayo-Muñoz, David ; Pinilla-Redondo, Rafael ; Camara-Wilpert, Sarah ; Birkholz, Nils ; Fineran, Peter C. / Inhibitors of bacterial immune systems : discovery, mechanisms and applications. In: Nature Reviews Genetics. 2024 ; Vol. 25, No. 4. pp. 237-254.

Bibtex

@article{a490354026f5479f9a68c1b1e120da5a,
title = "Inhibitors of bacterial immune systems: discovery, mechanisms and applications",
abstract = "To contend with the diversity and ubiquity of bacteriophages and other mobile genetic elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial defences include CRISPR–Cas, restriction–modification and a growing list of mechanistically diverse systems, which constitute the bacterial {\textquoteleft}immune system{\textquoteright}. As a response, bacteriophages and mobile genetic elements have evolved direct and indirect mechanisms to circumvent or block bacterial defence pathways and ensure successful infection. Recent advances in methodological and computational approaches, as well as the increasing availability of genome sequences, have boosted the discovery of direct inhibitors of bacterial defence systems. In this Review, we discuss methods for the discovery of direct inhibitors, their diverse mechanisms of action and perspectives on their emerging applications in biotechnology and beyond.",
author = "David Mayo-Mu{\~n}oz and Rafael Pinilla-Redondo and Sarah Camara-Wilpert and Nils Birkholz and Fineran, {Peter C.}",
note = "Publisher Copyright: {\textcopyright} Springer Nature Limited 2024.",
year = "2024",
doi = "10.1038/s41576-023-00676-9",
language = "English",
volume = "25",
pages = "237--254",
journal = "Nature Reviews. Genetics",
issn = "1471-0056",
publisher = "nature publishing group",
number = "4",

}

RIS

TY - JOUR

T1 - Inhibitors of bacterial immune systems

T2 - discovery, mechanisms and applications

AU - Mayo-Muñoz, David

AU - Pinilla-Redondo, Rafael

AU - Camara-Wilpert, Sarah

AU - Birkholz, Nils

AU - Fineran, Peter C.

N1 - Publisher Copyright: © Springer Nature Limited 2024.

PY - 2024

Y1 - 2024

N2 - To contend with the diversity and ubiquity of bacteriophages and other mobile genetic elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial defences include CRISPR–Cas, restriction–modification and a growing list of mechanistically diverse systems, which constitute the bacterial ‘immune system’. As a response, bacteriophages and mobile genetic elements have evolved direct and indirect mechanisms to circumvent or block bacterial defence pathways and ensure successful infection. Recent advances in methodological and computational approaches, as well as the increasing availability of genome sequences, have boosted the discovery of direct inhibitors of bacterial defence systems. In this Review, we discuss methods for the discovery of direct inhibitors, their diverse mechanisms of action and perspectives on their emerging applications in biotechnology and beyond.

AB - To contend with the diversity and ubiquity of bacteriophages and other mobile genetic elements, bacteria have developed an arsenal of immune defence mechanisms. Bacterial defences include CRISPR–Cas, restriction–modification and a growing list of mechanistically diverse systems, which constitute the bacterial ‘immune system’. As a response, bacteriophages and mobile genetic elements have evolved direct and indirect mechanisms to circumvent or block bacterial defence pathways and ensure successful infection. Recent advances in methodological and computational approaches, as well as the increasing availability of genome sequences, have boosted the discovery of direct inhibitors of bacterial defence systems. In this Review, we discuss methods for the discovery of direct inhibitors, their diverse mechanisms of action and perspectives on their emerging applications in biotechnology and beyond.

U2 - 10.1038/s41576-023-00676-9

DO - 10.1038/s41576-023-00676-9

M3 - Review

C2 - 38291236

AN - SCOPUS:85183628032

VL - 25

SP - 237

EP - 254

JO - Nature Reviews. Genetics

JF - Nature Reviews. Genetics

SN - 1471-0056

IS - 4

ER -

ID: 390288131