BioMatrix

Bacteria in nature live in biofilms. These biofilms are found everywhere; on plant roots, on decomposing organic material, in aquatic sediments and much more. Biofilms are useful in biotechnological applications, but they are also problematic, as they form at unwanted sites in industrial settings and can lead to chronic infections in humans.

Biofilms are assemblages of bacteria embedded in a matrix, produced by the bacteria themselves. When different types of bacteria live in proximity in a biofilm, we often identify features of this microbial community, which neither of the bacteria possess individually; examples include enhanced tolerance towards stress and inhibitors, and new metabolic capabilities. The interactions and mechanisms causing such “community properties” are largely unknown.

In BioMatrix, we will examine the matrix of biofilms comprised of multiple types of bacteria. We aim at identifying matrix components that directly impact functionality and/or tolerance of biofilms in nature. New experimental models will be designed to better mimic the real life of biofilm bacteria in nature.

BioMatrix will uncover fundamental mechanisms shaping bacterial communities and thereby close a primary knowledge gap in microbial ecology. Moreover, specific targets, facilitating efficient biofilm manipulation, are provided. This is useful in biotechnology for enhanced exploitation of bacterial community activity and in the development of novel and improved chronic infection treatment strategies.